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O'Keefe and Keefe, are the anglicised versions of the Irish Ó Caoimh, from Caomh, meaning "kind" or "gentle". Ó also means son of so directly translated the name means "Son of Kind" or "Son of Gentle". The original Caomh from whom the family descend, lived in the early eleventh century, and was descended from Cathal mac Finguine, celebrated King of Munster and the most powerful Irish king of the first half of the 8th century.